Regenerative Medicine and Device Innovation
Our current interests are focused on developing regenerative strategies for engineering tissues. Specifically, on-going projects focus on the employment of mechanical stimulation regimes in bioreactors to improve engraftment of bone and muscle substitutes. Our biomaterial philosophy is to use native tissue mimicking materials for the creation of scaffolds to serve as synthetic grafts. We have been using tools such as 3D printing to control scaffold architecture and study the impact of local matrix architecture and mechanical properties on influencing the development of tissue growth.
In support of the tissue regeneration efforts, we work on the correlation of in vivo tissue and vessel morphology using micro computed tomography or alternative image bases analyses to scaffold structure and bio-mechanical properties. Further, we are working on computational models to predict scaffold performance from a mechanical or tissue growth standpoint. The non-destructive evaluation of these properties along the translation of the scaffold from material synthesis, through in vitro testing and in vivo evaluation provides a powerful analysis tool with built in feedback for design improvements.